Subject: CHEMICAL PHYSICS OF BIOMOLECULES (A.A. 2020/2021)
Unit Chemical Physics of Biomolecules
Related or Additional Studies (lesson)
Knowledge and understanding
At the end of the course the student should be acquainted with the main biomolecules and the physico-chemical principles for the interpretation of their structure and their behavior.
Applying knowledge and understanding
At the end of the course the student should be able to apply the acquired knowledge to simple concrete problems in the field of the physical chemistry of biomolecules.
At the end of the course the student should be able to autonomously recognize the main features of biomolecules and to interpret them in the light of general physico-chemical principles.
At the end of the course the student should be able to orally report on the subjects that have been taught in the course, using a proper technical language
The study of physical chemistry of biomolecules, intrinsically multidisciplinary, allows the development of autonomous learning capabilities and of capabilities to deepen the knowledge of subjects that go beyond a monodiscipline background
Basic knowledge of Chemistry, to the level of Chemistry course for "Laurea Triennale" in Physics
• Review of the chemical bond theory: molecular orbital theory, bond order, VB theory and resonance, partial atomic charges, main features of the bonds relevant for biomolecules
• Optical isomerism: conformation and configuration, optical rotation, circular dichroism
• Intermolecular interactions: microscopic origin, relative strength in biomolecules
• Review of chemical kinetics and thermodynamics: reaction enthalpy, entropy and free energy; rate equations, transition state theory
• Water: physico-chemical properties and their molecular origin, ionic solutions, acids and bases.
• Proteins: amino acids, peptide bond, structure
• DNA: molecular component and structure of DNA
• Biomembranes: phospholipids and their chemistry, lipid double layer
Lecture Notes, Problems and Solutions Student consultation time: Friday 17-19 or by appointment to be asked by e-mail (email@example.com)
Examination: End-of-course oral assessment
P. Atkins, Physical Chemistry, Oxford University Press ed.
J. N. Israelachvili, Intermolecular and Surface Forces, Elsevier Ed. (Third Edition)
R. Garret, C. Grisham, Biochemistry, Thomson ed.